Fresh Mexican cuisine and drinks in a family friendly and vibrant setting. Proudly serving Certified Angus Beef Brand. Lunch specials.
Separate seating area for groups or watching sports games. Catering and takeout available or delivery through the CarGo application. Weekly specials including Kids Eat Free Monday, Two Dollar Tuesday, Fajita Wednesday, Burrito & Brew on Thursdays. Plus Happy Hour every day!
Based on 515 reviews, the restaurant has received a rating of 4.4 stars. Price $
✔️ Dine-in ✔️ Curbside pickup ✔️ Delivery
Address:
1832 N Kingshighway St, Cape Girardeau, MO 63701
Phone: (573) 335-9690
Social Profile: 

Hours
| Monday
(Labor Day)
|
11 AM–9 PM
Hours might differ
|
| Tuesday | 11 AM–9 PM |
| Wednesday | 11 AM–9 PM |
| Thursday | 11 AM–9 PM |
| Friday | 11 AM–10 PM |
| Saturday | 11 AM–10 PM |
| Sunday | 11 AM–9 PM |
Menu
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Photo Gallery
Reviews
Leah Harris
We went to Seis Amigos for dinner last night and sat at their outdoor patio. We had no wait to be seated and the service was great. We both got street tacos with corn tortillas and my husband ordered a strawberry margarita. He was surprised by how big the medium margaritas were. All of the food was delicious, however we both had gluten reactions later that evening. In my experience Mexican restraunts are usually a safe choice if you’re gluten sensitive because they have so many corn-based options. I’m not sure if they use flour in their seasonings or if it was simply a cross contamination issue in the kitchen. The food was great and if gluten isn’t a concern for you, you’ll likely have a great experience. However, if you’re sensitive to gluten, use caution here.
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Tina G.
First time here. We ordered our meals, and my husband and I both ordered Golden Margaritas. We ordered the large. Our server charged us for 2 pitchers instead of 2 large, which is a HUGE price difference. According to the manager, she doesn’t speak good English and always confuses the large and the pitcher.
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Becca Sides
Amazing, fast service and delicious food!!! Great prices! I could not believe how fast the turnaround time was between when we ordered and when fresh, hot food came out! They served the kids first which was perfect because they take the longest to eat and are least patient. We were blown away! Definitely will be going back!!!
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That Guy
Food was great, service was excellent. If you like Mexican food this is the place.
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Christina
Seated quickly. Steak fajitas was big enough for two!! Very tasty. Shrimp quesidilla hard lots of Shrimp and was good. Kiddo did not care for cheese quesidilla, so wasted money on that…Be sure to check your bill as I ordered the special and it included a drink. Charged regular snd for drink, but changed when brought to their attention. Took FOREVER to get our bill!! Prices seem high. Common complaint.
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Divya Prabhu
Super impressed. Wonderful Mexican food. Lovely service. Special shoutout to our server, she was really nice. I got the Tacos ala Mexicana, with chicken and chorizo. Delicious. And the frozen Margarita was a cherry on the cake.
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April Ahrens
Absolutely delicious. I went there with my husband and some friends, our service was excellent, my street tacos were delicious, the salsa was great, and the guacamole amigo was also great. Loved it and will definitely be back!
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Mike Freeman
Seis amigos- you are no friends of mine. Asked for delivery but had to pickup order for 20 co-workers. Still charged $15 for ?containers. Came to ABOUT $430 – about $22 per person for TACOS. Food was fair. Certainly not the best I’ve had even here in Cape. Guacamole was very good- thus the 2 stars. Horribly overpriced but manager didn’t seem to think so. Would advise to stay away. Much better options even here in Cape.
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Marshall Currin
I had the food delivered and it was awesome. Food was still hot and very delicious. This is my first time having seis amigos.
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Greg Eddy
It was a very popular place. Food was very good but there were too many people who didn’t really understand English. I asked for a Diet Coke and got Mr Pibb. My wife asked about a drink and the server had to go ask someone else. Also there were not many choices for my wife, who does not eat meat. As I said, the food was excellent and the prices were reasonable.
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